Novel protein, MINDY4 and Aquaporin 1 readthrough (No standardized abbreviation; ENSG00000250424 is used for locus identification, but not as a canonical protein abbreviation)

The ENSG00000250424 locus encodes a predicted protein resulting from a readthrough transcriptional event between the *MINDY4* deubiquitinating enzyme gene and the *Aquaporin 1 (AQP1)* water channel gene[2][5]. Readthrough, or transcriptional/ translational continuation from one coding region into another, sometimes produces novel fusion proteins, but such variants are often not well-characterized or may represent artifacts rather than functional proteins. For ENSG00000250424, there is no evidence of physiological relevance, therapeutic targeting, or association with disease. The best-characterized aspects pertain to the parent proteins: MINDY4 acts as a K48-specific deubiquitinase involved in protein turnover; AQP1 mediates water transport across membranes[3][5]. This readthrough gene is not a recognized therapeutic target, and its protein product is likely poorly understood, noncanonical, and may not exist as a biologically significant molecule.

Other names

ENSG00000250424Novel protein, MINDY4 and AQP1 readthrough