Novel protein, PPM1B-SLC3A1 readthrough (PPM1B-SLC3A1 readthrough (no established abbreviation beyond gene-centric references))

The "PPM1B-SLC3A1 readthrough" is a genomic fusion transcript produced by transcriptional readthrough at the adjacent loci of **PPM1B** (protein phosphatase, Mg2+/Mn2+ dependent 1B) and **SLC3A1** (solute carrier family 3 member 1) on chromosome 2p21[2][6]. Readthrough events typically result in rare, chimeric transcripts that are not frequently translated or functionally relevant. Neither the protein product nor its biological function is well characterized, and it is not recognized as a valid therapeutic target. The parent proteins are individually associated with metabolic regulation (PPM1B) and amino acid transport (SLC3A1)[7][9][1][4], and deletions spanning their loci are linked to rare syndromes such as hypotonia-cystinuria. However, the fusion product does not have clear disease association, pharmacological relevance, or established role in human health or disease.

Other names

PPM1B-SLC3A1 fusionENSG00000285542 (Ensembl transcript ID)Novel protein, PPM1B-SLC3A1 readthrough

No drugs are known to interact with or modulate the function of the readthrough protein