Novel transcript, antisense to acyl-CoA thioesterase 6

This transcript is a non-coding RNA expressed from the DNA strand opposite to the ACOT6 gene, rendering it an "antisense" RNA. Such antisense transcripts are widely present in human genomes and can affect the expression and chromatin state of their corresponding sense gene. Mechanistically, antisense RNAs can mediate transcriptional interference (by colliding RNA polymerases), mask splicing or regulatory sequences in the sense transcript, form double-stranded RNA leading to degradation or RNA interference, or influence chromatin remodeling and histone modification[1][2]. In the case of the "novel transcript, antisense to ACOT6," no specific biological function, disease connection, or therapeutic target status has been established. It remains an annotated, but uncharacterized, non-coding RNA in genomic databases.

Other names

ENSG00000258603antisense to ACOT6

Transcriptional interference; RNA masking and possible modulation of epigenetic marks such as histone acetylation