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Novel transcript, antisense to BMP4 (ENSG00000287156)

Target
ENSG00000287156
Molecular classification
Other (antisense RNA, non-coding RNA)
01

Overview

This entry corresponds to a long non-coding RNA (lncRNA) transcript that is transcribed in the antisense orientation relative to the *BMP4* gene (bone morphogenetic protein 4). Antisense transcripts are typically involved in regulating the expression of their sense partner genes through mechanisms such as chromatin remodeling, transcriptional interference, or modulation of mRNA stability. In this case, the "novel transcript, antisense to BMP4" is not a protein, enzyme, receptor, or other canonical molecular target used in drug discovery, and its molecular function—if any—remains uncharacterized in public databases. There is currently no evidence it serves as a direct therapeutic target, nor are there known drugs, biomarkers, or safety concerns associated with it. Additional context: - *BMP4* is an important developmental signaling molecule, but this antisense transcript does not encode BMP4 or function as a receptor/enzyme. - “Uncharacterized protein LOC124903317” may be a misnomer. Based on available gene models, this locus does not code a characterized protein and is classified as a non-coding (antisense) transcript in public databases. - Antisense RNAs to developmental genes like *BMP4* can modulate sense gene expression, but direct disease, drug, or biomarker links for this specific transcript have not been described in the available literature or annotation sources. Summary of issues: - This is not a validated drug target or canonical receptor/protein; it is a predicted non-coding transcript whose function is unproven and ambiguous, thus **is_target=false** and **is_incorrect=true**. - There is no evidence for interacting drugs, mechanisms of action, or disease roles beyond speculative gene regulation.

Other names
LOC124903317uncharacterized protein LOC124903317ENSG00000287156antisense BMP4 transcript
02

Biological functions

Regulation of gene expression (epigenetic or RNA-level modulation)
03

Disease associations

Other (potential regulatory involvement in BMP4-related processes, but no direct association with disease established)

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