Novel transcript, antisense to CST6 (ENSG00000298934)

This transcript is an RNA gene located antisense to the CST6 locus, and is not considered to be a canonical therapeutic target. It belongs to a class of non-coding RNAs, specifically an antisense transcript, which can modulate the expression and chromatin environment of the sense gene CST6 by altering rates of transcription initiation, transcript processing, and nuclear export[1][2][4]. Antisense transcription events like this one are increasingly recognized for their genome-wide impact on regulation but are typically not druggable or considered receptors, enzymes, or classical targets. The principal biological relevance is indirect, through modulation of the CST6 gene, which encodes cystatin E/M, an inhibitor of cathepsins often silenced by methylation in brain tumors[6]. No drugs, biomarkers, or disease roles are specifically associated with ENSG00000298934.

Other names

Novel transcript antisense to CST6ENSG00000298934

Not applicable; however, antisense transcripts can modulate gene expression of protein-coding genes such as CST6[2][4]