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Novel transcript, antisense to LIPA (ENSG00000232110 (or LOC124902477, as used in some databases))

Target
ENSG00000232110 (or LOC124902477, as used in some databases)
Molecular classification
Long non-coding RNA (lncRNA)
01

Overview

ENSG00000232110 is a human long non-coding RNA (lncRNA) gene annotated as "novel transcript, antisense to LIPA" and also known by the locus identifier LOC124902477. It is transcribed in the opposite orientation to the LIPA gene—an enzyme involved in cholesterol metabolism—but does not code for a protein itself. lncRNAs of this type are often involved in regulating their sense gene counterparts at the RNA or chromatin level through mechanisms such as RNA masking, transcriptional interference, or the production of double-stranded RNA that can participate in regulatory or silencing pathways[1][5]. However, there is no direct evidence to date defining the exact biological function or disease relevance of ENSG00000232110 specifically. It is not considered a therapeutic target or biomarker in clinical or translational research databases. This target follows standard naming conventions as a non-protein-coding RNA, with no functional data linking it to disease or drug action at present[1][6].

Other names
LOC124902477novel transcript, antisense to LIPAENSG00000232110
02

Biological functions

Other (potential regulation of LIPA gene expression; lncRNAs often regulate transcription, stability, or translation of overlapping protein-coding genes through mechanisms such as RNA masking, transcriptional interference, or chromatin remodeling[5])
03

Disease associations

Unknown/Other (no direct disease associations currently reported)

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