Novel transcript, antisense to MGMT

ENSG00000296036 encodes a long non-coding RNA transcript that is transcribed antisense to the MGMT locus. Antisense lncRNAs can affect the expression and stability of their overlapping protein-coding genes, often through modulation of local chromatin state or by directly interacting with the partner mRNA. For many such antisense RNAs, including those near critical genes like MGMT, emerging research indicates a potential regulatory role in gene expression, potentially influencing response to chemotherapy in cancers such as glioma; however, there is no established therapeutic targeting of this transcript, nor validated disease associations specific to this lncRNA aside from its genomic position and putative regulatory potential.

Other names

ENSG00000296036antisense MGMT lncRNA