Novel transcript, antisense to NDUFA1 and AKAP14 (ENSG00000297015)

ENSG00000297015, annotated as "novel transcript, antisense to NDUFA1 and AKAP14," is a predicted non-coding RNA gene on the X chromosome located in an antisense orientation to the coding genes NDUFA1 (NADH:Ubiquinone Oxidoreductase Subunit A1) and AKAP14 (A-kinase anchoring protein 14)[1][2]. There is no experimental evidence supporting a functional role or association with disease, and it is not considered a therapeutic target, receptor, enzyme, transporter, or any canonical druggable protein. No drugs, clinical data, or validated biological functions are currently assigned to this locus. “Antisense” refers to its transcript overlapping and running in the opposite direction to parts of NDUFA1 and AKAP14, but its function, protein-coding status, and clinical significance are unknown. Therefore, it should not be treated as a canonical or actionable target for drug discovery. If you require validated information for NDUFA1 or AKAP14 themselves, both are protein-coding genes with established functions, but this “novel transcript” is not an established molecular target for therapeutics[1][2][3][4].