Novel transcript, antisense to PHGDH

ENSG00000296672 is an uncharacterized long non-coding RNA that lies antisense to the PHGDH locus. PHGDH encodes the enzyme 3-phosphoglycerate dehydrogenase, which catalyzes the first step in the serine biosynthesis pathway and has implications in cancer resistance[3][1]. However, the biological significance of this antisense RNA transcript remains unstudied; it is catalogued in functional genomics repositories such as Ensembl and GeneCards but lacks experimentally validated attributes, aliases, or any connection to canonical protein targets or therapeutic agents[5]. It is not a canonical receptor, enzyme, transporter, transcription factor, or any other characterized target class. For drug discovery, this transcript should not be considered a validated molecular target. ENSG00000296672 represents a non-coding RNA, not a protein-coding gene or therapeutic target. Its “target” status is incorrect for drug discovery or target annotation. No aliases, functional classification, disease association, or drug interaction data are available[5]. For structured databases and curation, use the canonical information for PHGDH and disregard this transcript unless future research validates functional or therapeutic relevance.

Other names

ENSG00000296672