Novel transcript, antisense to pregnancy zone protein (ENSG00000309149)

This entry refers to a natural antisense transcript (NAT) located antisense to the Pregnancy zone protein (PZP) gene. NATs are RNA molecules transcribed from the opposite strand of a protein-coding gene; they generally do not code for proteins themselves but have important regulatory functions. These functions may include repression or, less commonly, activation of the sense gene (PZP in this case) via various mechanisms: transcriptional interference, recruitment of chromatin modifiers for epigenetic silencing, RNA masking, RNA editing, and formation of double-stranded RNAs that trigger RNA interference. Antisense RNAs are widespread in the human genome and serve as critical modulators of gene expression, but they are usually not considered therapeutic targets themselves, nor do they have direct drug interactions. There is no evidence that this specific antisense transcript is a therapeutic target, or that it directly interacts with drugs. Additionally, the label "novel transcript, antisense to PZP" together with the uncharacterized Ensembl ID (ENSG00000309149) means this entity is not yet a well-characterized molecule, and likely not a correct entry for a canonical, actionable drug target. Most often, these transcripts serve to fine-tune gene expression and can be implicated indirectly in disease via altered expression of their sense partners[1][2][3][4][5].

Other names

antisense transcript to PZPnovel transcript antisense to PZPENSG00000309149