Novel transcript, antisense to solute carrier family 22 member 23 (ENSG00000272320)

This is a natural antisense transcript complementary to the SLC22A23 gene, which codes for a solute carrier family transporter. Natural antisense transcripts can influence the expression of their sense gene partners through various mechanisms, including altering chromatin states, modulating mRNA stability, and interfering with transcription. Antisense transcription is widespread in the genome and may fine-tune protein-coding gene output, but the biological significance and potential therapeutic utility of any specific antisense transcript (such as the one antisense to SLC22A23) remain largely uncharacterized. This entity is distinct from SLC22A23, which is a transmembrane transporter protein. SLC22A23 itself has limited–but some–association with disease, but the antisense RNA has not been documented as a direct disease gene or therapeutic target. Natural antisense transcripts can play complex and diverse regulatory roles but are rarely direct drug targets themselves in current drug discovery paradigms.

Other names

antisense to SLC22A23ENSG00000272320

Not applicable for drug targeting. Potential regulatory mechanisms include: transcriptional interference, RNA masking, dsRNA formation, RNA interference, modulation of chromatin state.