novel transcript, antisense to TACR2 (ENSG00000299486)

"novel transcript, antisense to TACR2" (ENSG00000299486) is an annotated noncoding RNA locus overlapping the TACR2 gene in an antisense orientation. Natural antisense transcripts are widespread in the human genome and often function by regulating the expression of their corresponding sense gene through diverse mechanisms, including RNA masking, modulation of alternative splicing, recruitment of chromatin-modifying complexes, and transcriptional interference[2][4][5]. While the functional significance of the specific antisense transcript at this locus remains unknown, NATs can affect the stability, splicing, or translation of the corresponding sense mRNA, or recruit epigenetic silencing marks. There is no evidence that this particular transcript is a protein, a therapeutic target, or has established clinical relevance independently from its sense gene (TACR2)[1]. This transcript is sometimes included in gene annotation databases due to widespread antisense transcription, but unless specific functional, clinical, or mechanistic data are published, it should not be regarded as a therapeutic target. The canonical protein-coding gene at this locus is Tachykinin receptor 2 (TACR2), also known as NK2R[1]. If information was actually sought for TACR2 or NK2R (a G protein-coupled receptor), refer directly to its established gene/protein entry.

Other names

antisense to TACR2ENST00000620452TACR2-AS