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ENSG00000304335 is a long non-coding RNA transcript located antisense to the TPP1 gene. As an lncRNA, it does not encode a protein but may play a regulatory or structural role at the RNA level. There is currently no published evidence directly connecting this transcript to well-characterized biological processes, clinical phenotypes, or therapeutic drug targeting. Its annotation and naming may vary across databases and is not standardized in the scientific literature[3]. The entry refers to a non-coding RNA, not the "Tripeptidyl-peptidase 1" protein (TPP1), which is a well-characterized lysosomal enzyme involved in late-infantile neuronal ceroid lipofuscinosis (CLN2)[1][2][4][5][7]. Therefore, this transcript should not be treated as a conventional drug target, receptor, enzyme, or biomarker. For comprehensive pharmaceutical or biomedical research, the protein-coding TPP1 would be the relevant gene, not this antisense lncRNA[3].
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