novel transcript, antisense to YARS2

Novel transcript, antisense to YARS2" (ENSG00000286950) is a non-coding genomic region annotated as transcribed in the antisense orientation relative to the YARS2 gene, which encodes mitochondrial tyrosyl-tRNA synthetase[4][2][1]. There is no evidence in the current literature or genomics databases that this antisense transcript produces a functional protein or acts as a direct therapeutic target. It is not classified as a receptor, enzyme, transporter, or other druggable protein. Information on function, disease association, drugs, or clinical utility for this transcript is lacking, as is evidence of its use as a biomarker or its involvement in safety or therapeutic concerns. This entry represents an uncharacterized or hypothetical transcript rather than a validated molecular target. YARS2 (the sense gene) is a well-studied mitochondrial enzyme with involvement in mitochondrial protein synthesis and various diseases including mitochondrial myopathies and potentially certain cancers[1][2][4], but the antisense transcript to YARS2 has no established role or characterization in molecular biology or medicine. It is not uncommon for large-scale genomic annotation projects to predict or annotate antisense and non-coding transcripts without clear evidence of functional relevance. ENSG00000286950 appears to be such a prediction, with no current evidence of a biological, pharmacological, or clinical role.

Other names

ENSG00000286950antisense to YARS2