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ENSG00000277945 refers to a novel, sense, intronic transcript within the HMGA2 gene locus. It is classified as a non-coding RNA and does not encode a protein. There is currently no evidence that this RNA is a therapeutic target, nor does it have known molecular functions or disease associations distinct from those of the HMGA2 gene itself. Most available annotations provide only its genomic location and transcriptional orientation with respect to HMGA2, and there is no data on expression, function, or clinical relevance[4]. HMGA2 (High Mobility Group AT-hook 2) is a protein-coding gene involved in transcriptional regulation, oncogenesis, and is studied as a biomarker in various cancers[1][2][3]. The transcript ENSG00000277945 is identified in annotations as an intronic, sense (same-strand) RNA gene within HMGA2, but lacks evidence of protein-coding capability or established functional annotation[4].
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