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Target intelligence / Profile preview
NR2B Subunit-Containing N-Methyl-D-Aspartate (NMDA) Receptor (NR2B-NMDA Receptor)
- Target
- NR2B-NMDA Receptor
- Molecular classification
- Ion channel, Ligand-gated ion channel, Receptor, Glutamate Receptor
01
Overview
The NR2B subunit-containing NMDA receptor is a subtype of the ionotropic glutamate receptor, specifically a variant that incorporates the NR2B (GluN2B or GRIN2B) subunit. It plays a critical role in synaptic transmission, plasticity, and various physiological and pathological processes in the central nervous system. It is a heterotetramer composed of two GluN1 subunits and two NR2B subunits, forming a ligand-gated ion channel permeable to Ca²⁺, Na⁺, and K⁺. It is implicated in learning, memory, pain modulation, and circadian rhythm, and is linked to neurological disorders like chronic pain, neurodegenerative diseases, and psychiatric conditions. Selective antagonists targeting this subunit have shown promise for therapeutic intervention.
- Other names
- Glutamate [NMDA] receptor subunit epsilon-2GluN2BGRIN2B
02
Mechanism of action
Ligand-gated ion channel blocking, allosteric modulation
03
Biological functions
Synaptic transmissionSynaptic plasticityLong-term potentiation (LTP)Learning and memoryModulation of pain perceptionRegulation of feeding behaviorsCircadian rhythm regulation
04
Disease associations
Chronic pain syndromesNeurodegenerative diseasesPsychiatric conditionsDepressionSchizophrenia
05
Safety considerations
Potential for cognitive side effects with non-selective NMDA receptor antagonists.Development of tolerance or dependence.Risk of excitotoxicity with excessive activation.
06
Interacting drugs
Ifenprodil
3 more in the full profile.
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