Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
NUBP iron-sulfur cluster assembly factor, mitochondrial (NUBPL)
- Target
- NUBPL
- Molecular classification
- Iron-sulfur cluster assembly factor, Enzyme cofactor assembly protein, P-loop NTPase family, Other
01
Overview
NUBP iron-sulfur cluster assembly factor, mitochondrial (NUBPL), is an essential protein involved in the transfer of iron-sulfur (Fe-S) clusters to subunits of mitochondrial Complex I (NADH:ubiquinone oxidoreductase) during its assembly. It acts as a dedicated Fe-S cluster maturation factor, delivering [4Fe-4S] clusters to specific subunits of Complex I, and is classified as a P-loop NTPase. Mutations in the NUBPL gene are associated with mitochondrial complex I deficiency, causing a range of mitochondrial disorders that predominantly involve neurological dysfunction and multisystem disease. NUBPL is not a classic therapeutic target such as a receptor or enzyme, but is clinically significant due to its role in inherited mitochondrial diseases.
- Other names
- Iron-sulfur cluster transfer protein NUBPLIND1IND1 homologC14orf127FLJ12660MC1DN21huInd1nucleotide-binding protein-likeiron-sulfur protein required for NADH dehydrogenase
02
Biological functions
Iron-sulfur cluster transferAssembly of mitochondrial Complex I (NADH:ubiquinone oxidoreductase)Mitochondrial respiratory chain biogenesisOther
03
Disease associations
Mitochondrial diseaseNeurodegenerative diseaseMitochondrial complex I deficiencyOther
04
Safety considerations
Mitochondrial dysfunction due to deficiency or mutationPotential for multisystem disease in affected patients
05
Biomarkers
NUBPL mutations as biomarker for mitochondrial complex I deficiency
Beyond the preview
Go deeper on NUBP iron-sulfur cluster assembly factor, mitochondrial (NUBPL).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on NUBP iron-sulfur cluster assembly factor, mitochondrial (NUBPL).