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Nuclear-encoded mitochondrial transfer RNA glutamine (anticodon TTG) 12-1 pseudogene (NMTRQ-TTG12-1)

Target: NMTRQ-TTG12-1
Molecular classification: Non-coding RNA, Pseudogene, tRNA (predicted, pseudogene)

Overview

Nuclear-encoded mitochondrial tRNA-Gln 12-1 (NMTRQ-TTG12-1, also known as TRNAQ41P, nmt-tRNA-Gln-TTG-12-1, and transfer RNA glutamine 41 (anticodon UUG) pseudogene) is annotated as a **nuclear tRNA pseudogene** and is not functionally involved in mitochondrial translation or protein synthesis. Mitochondrial tRNAs required for translation in human mitochondria are encoded in the mitochondrial genome, with all tRNA genes, including tRNA-Gln, located on mtDNA rather than the nuclear genome[1][2][3]. The presence of a pseudogene in the nuclear genome does not correspond to any known therapeutic, regulatory, or enzymatic activity, nor is it druggable or clinically relevant. There is no evidence for any biological activity or disease association with this locus.

Other names: nmt-tRNA-Gln-TTG-12-1TRNAQ41Ptransfer RNA glutamine 41 (anticodon UUG) pseudogenetransfer RNA-Gln (TTG) 12-1nuclear-encoded mitochondrial tRNA-Gln (TTG) 12-1nmt-tRNA-Gln-TTG-12-1, NMTRQ-TTG12-1

Mechanism of action

Not applicable.

Biological functions

None known; pseudogenes do not have active biological functions.If it were a true tRNA, the role would be in "Mitochondrial translation," but that does not apply for a pseudogene[1][2][3].

Disease associations

None known.No association with human disease reported; mitochondrial tRNA mutations (encoded in mtDNA) may cause disease, but pseudogenes in the nuclear genome have no established disease links.

Safety considerations

None.

Interacting drugs

None.

Biomarkers

None.

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