Nuclear factor erythroid-derived 2-like 2 pseudogene (NFE2L2 pseudogene) (NFE2L2 pseudogene; alternatively, NMRAL2P)

This locus (ENSG00000224967) refers to the NmrA-like redox sensor 2 pseudogene (NMRAL2P), a functional pseudogene and non-coding RNA. It is directly regulated by the transcription factor Nrf2 (NFE2L2) and acts as a co-regulator of Nrf2-dependent gene induction, specifically enhancing induction of NAD(P)H quinone dehydrogenase 1 (NQO1) in human colon cancer cells treated with the dietary anticancer agent sulforaphane. Unlike conventional protein-coding targets, NMRAL2P does not encode a functional protein, but its RNA product has regulatory roles and influences cell viability and migration in experimental cancer models. This locus is not a therapeutic target in drug discovery, as it does not encode a protein or catalytically active agent, but its activity as a regulatory RNA highlights emerging functions of pseudogenes beyond being nonfunctional DNA. ENSG00000224967 is misclassified if considered a receptor or concordant drug target. It is a regulatory pseudogene, with functional non-coding RNA roles, most notably as the NmrA-like redox sensor 2 pseudogene (NMRAL2P) in the Nrf2 pathway in cancer research models.

Other names

NFE2L2 pseudogeneNmrA-like redox sensor 2 pseudogene (NMRAL2P)LOC344887

RNA-level co-regulation: NMRAL2P modulates induction of NQO1 by Nrf2 in response to sulforaphane in cancer cells. Not a typical druggable mechanism (e.g., ligand binding to a receptor).