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Target intelligence / Profile preview
Nuclear Factor kappa-light-chain-enhancer of activated B cells (NF-κB) pathway
- Molecular classification
- Signaling pathway, Transcription factor regulator
01
Overview
NF-κB is a family of transcription factors that regulate genes involved in immune responses, inflammation, cell proliferation, apoptosis, and cellular stress responses. The pathway is activated by various stimuli, leading to the translocation of NF-κB dimers into the nucleus where they bind DNA and regulate gene expression. Dysregulation of the NF-κB pathway is implicated in numerous diseases, including cancer, autoimmune disorders, and inflammatory diseases.
02
Mechanism of action
Inhibition of NF-κB activation; modulation of downstream gene expression
03
Biological functions
Immune responseInflammationCell proliferationApoptosisCellular stress responseGene expression regulation
04
Disease associations
CancerRheumatoid arthritis (RA)Inflammatory bowel disease (IBD)Asthma/chronic obstructive pulmonary disease (COPD)Viral infections (HIV etc.)Autoimmune diseasesChronic inflammatory disorders
05
Safety considerations
ImmunosuppressionIncreased risk of infectionPotential for off-target effects due to broad role in cellular processes
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