Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Nuclear poly(ADP-ribose) polymerase 1 (PARP-1)
- Target
- PARP-1
- Molecular classification
- Enzyme, ADP-ribosyltransferase
01
Overview
Nuclear poly(ADP-ribose) polymerase 1 (PARP-1) is a multifunctional nuclear enzyme that plays critical roles in DNA repair, chromatin remodeling, transcription regulation, and cell death pathways. It detects DNA strand breaks and synthesizes poly(ADP-ribose) (PAR) chains, signaling DNA damage and recruiting repair proteins. PARP-1 is involved in multiple DNA repair pathways and regulates transcription/chromatin structure. Inhibition of PARP-1 is a therapeutic strategy, particularly in cancers with BRCA mutations or other homologous recombination deficiencies.
- Other names
- ADPRT1Poly[ADP-ribose] polymerase 1PARP1
02
Mechanism of action
Inhibition of PARP-1 enzymatic activity, leading to accumulation of DNA damage and cell death, especially in HR-deficient cells
03
Biological functions
DNA repairChromatin remodelingTranscription regulationCell deathGenome maintenanceRegulation of differentiationRegulation of proliferationTumor transformationModulation of inflammation
04
Disease associations
CancerFanconi anemiaType I diabetesInflammation
05
Safety considerations
Toxic lesionsPotential for off-target effects
06
Interacting drugs
PARPi drugs
1 more in the full profile.
07
Biomarkers
BRCA mutationsHR deficiency
Beyond the preview
Go deeper on Nuclear poly(ADP-ribose) polymerase 1 (PARP-1).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Nuclear poly(ADP-ribose) polymerase 1 (PARP-1).