Target intelligence / Profile preview

Nucleoprotein (Marburg Virus) (NP)

Target
NP
Molecular classification
Structural protein
01

Overview

The nucleocapsid protein (NP) of Marburg virus (MARV) is the major structural component of the viral nucleocapsid. It plays a central role in encapsidating the viral RNA genome, forming a left-handed helical complex that serves as a scaffold for nucleocapsid assembly and is essential for viral transcription and replication. It interacts with VP35, VP30, L, VP40, and VP24. The protein is heavily phosphorylated and only phosphorylated forms are incorporated into virions.

Other names
Nucleocapsid protein
02

Biological functions

vRNA encapsidationViral transcriptionViral replicationNucleocapsid assemblyBudding
03

Disease associations

Infection

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