Nucleotide-binding oligomerization domain-containing protein 2 (NOD2) mRNA (NOD2 mRNA)

Nucleotide-binding oligomerization domain-containing protein 2 (NOD2) mRNA is the messenger RNA transcript that encodes the NOD2 protein, a critical cytosolic pattern recognition receptor (PRR) of the innate immune system [1]. The encoded protein functions by detecting muramyl dipeptide (MDP), a conserved component of bacterial peptidoglycan, which triggers the activation of NF-κB and MAPK signaling pathways to initiate an inflammatory response [2]. Genetic variations in the NOD2 mRNA sequence, such as the 1007fs mutation, are strongly linked to the pathogenesis of Crohn's disease, where impaired bacterial sensing leads to chronic intestinal inflammation [3]. In contrast, gain-of-function mutations are associated with Blau syndrome, a systemic granulomatous disease [4]. While small molecule inhibitors currently target the NOD2 protein or its downstream effector RIPK2, the NOD2 mRNA is being investigated as a target for RNA-based therapeutics, including siRNAs and antisense oligonucleotides, to precisely modulate protein expression [5]. This approach holds potential for treating autoinflammatory conditions where NOD2 signaling is pathologically elevated [6]. Sources: [1] UniProt (Q9HC29); [2] PubMed (PMID: 11349144); [3] NCBI Gene (ID: 64127); [4] Nature Genetics (PMID: 11687795); [5] Journal of Biological Chemistry (PMID: 16272247); [6] Nature Reviews Immunology (PMID: 16456516).

Other names

CARD15 mRNAIBD1 mRNANLRC2 mRNANucleotide-binding oligomerization domain-containing protein 2 transcript

RNA interference (RNAi) and antisense-mediated degradation of the mRNA transcript to prevent translation of the NOD2 protein.