null (not a single molecule; collective term for multiple genes including KIF1Bβ, CHD5, CAMTA1, PHB) (null)

Multiple oncogenic differentiation-modulating genes in neuroblastoma" describes a set of genes, often at chromosome 1p36, that promote neuronal differentiation and act as tumor suppressors when functional, with loss driving aggressive, undifferentiated tumors. KIF1Bβ exemplifies this by transporting the NGF receptor TRKA to enable differentiation, apoptosis in progenitors, and sympathetic nervous system development; its mutations or deletion impair these processes, mimicking high-risk neuroblastoma transcriptomes independent of MYCN. [1] Other genes like CHD5 and CAMTA1 support terminal neuronal differentiation, while PHB overexpression on 17q gain suppresses differentiation programs, boosting proliferation and poor prognosis. [3][4] These genes' dysregulation underlies neuroblastoma's hallmark failure of neural crest cells to mature, contributing to heterogeneity from spontaneous regression in low-risk cases to fatal high-risk disease. No direct drugs target them, but their roles highlight differentiation therapy potential, akin to retinoic acid use. [5][11] Low expression generally predicts unfavorable outcomes, linking to 1p loss seen in 25-35% of cases. [1][4]

Other names

1p36 tumor suppressorsdifferentiation regulators in neuroblastomaneural differentiation genes (e.g., sympathoadrenal lineage genes)