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Target intelligence / Profile preview
NY-ESO-1(157–165) peptide presented by HLA-A*02:01
- Molecular classification
- Peptide-MHC Complex, MHC Class I, Tumor-associated antigen
01
Overview
The NY-ESO-1(157–165)/HLA-A*02:01 complex is a peptide derived from the cancer/testis antigen NY-ESO-1, presented by the HLA-A*02:01 MHC class I molecule. This complex serves as an immunogenic target for CD8+ T cells and is used in cancer immunotherapy strategies such as vaccines and adoptive cell therapies. The specific peptide sequence is SLLMWITQC.
- Other names
- HLA-A*02:01/NY-ESO-1(157–165) complexNY-ESO-1 SLLMWITQC / HLA-A*02:01NY-ESO-1 peptide presented by histocompatibility leukocyte antigen A*02
02
Mechanism of action
Target for T-cell based immunotherapies
03
Biological functions
Antigen presentationT cell activationImmune response
04
Disease associations
CancerMelanomaTriple-negative breast cancer
05
Safety considerations
On-target off-tumor toxicityCytokine release syndromeGraft-versus-host disease
06
Biomarkers
NY-ESO-1 expressionHLA-A*02:01 status
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