O-linked N-acetylglucosamine transferase (OGT) mRNA (OGT mRNA)

O-linked N-acetylglucosamine transferase (OGT) mRNA is the transcript encoding the OGT enzyme, which is the sole mediator of O-GlcNAcylation in the nucleus and cytoplasm (UniProt P51333). This post-translational modification involves the attachment of a single N-acetylglucosamine sugar to serine or threonine residues, serving as a critical nutrient sensor that integrates metabolic status with cellular signaling (NCBI Gene 8473). OGT mRNA is frequently overexpressed in various malignancies, including breast, prostate, and colorectal cancers, where it drives oncogenic signaling by stabilizing proteins like c-Myc and cyclin D1 (PubMed: 30104345). In metabolic disorders, elevated OGT mRNA levels are associated with insulin resistance and the progression of diabetic complications (PubMed: 23023793). Targeting OGT mRNA via RNA interference (siRNA) or antisense oligonucleotides (ASOs) represents a therapeutic strategy to downregulate OGT protein levels and mitigate pathological O-GlcNAcylation (PubMed: 23023793). However, because OGT is essential for fundamental cellular processes and embryonic development, therapeutic interventions must carefully balance efficacy with the risk of systemic toxicity and metabolic disruption (UniProt P51333).

Other names

O-GlcNAc transferase mRNAUDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase mRNAOGT transcriptHRNT77 mRNA

RNA interference (siRNA) or RNase H-mediated degradation (ASO) leading to reduced OGT protein expression