OBI1 antisense RNA 1 (lncRNA) (OBI1-AS1)

OBI1 antisense RNA 1 (OBI1-AS1) is a long non-coding RNA (lncRNA) gene located on human chromosome 13q22.3, transcribed from the antisense strand relative to the ORC ubiquitin ligase 1 (OBI1) and also referred to by aliases such as POU4F1-AS1 and RNF219-AS1[4][3][5]. OBI1-AS1 has been identified as a highly specific marker for astrocytes and shows epigenetically reduced expression in glioblastoma multiforme (GBM), with its expression levels correlated with patient survival outcomes[1][5]. Its functions are associated with the regulation of synaptic signal transduction pathways, and possibly with neural development and pluripotency[1][3]. Differential variants of OBI1-AS1 also show associations with attention-deficit/hyperactivity disorder (ADHD), affecting both disease risk and symptom severity, likely through genetic polymorphisms at several SNP loci[5]. OBI1-AS1 participates in gene regulation through mechanisms typical of lncRNA and antisense RNA, such as modulating chromatin structure and interacting with transcriptional machinery[2]. While not a direct therapeutic target in the classic sense (e.g., receptor or enzyme), OBI1-AS1 is of growing interest as a disease biomarker, particularly for glioma/GBM diagnosis, prognosis, and possibly for neuropsychiatric disorders[1][5]. Note: There are currently no known drugs directly targeting OBI1-AS1, and its mechanisms of action as a therapeutic target have not yet been established. Its principal utility lies in biomarker development and research into the molecular pathology of gliomas and neurodevelopmental disorders[1][3][5].

Other names

POU4F1-AS1RNF219-AS1POU4F1 antisense RNA 1 (non-protein coding)RNF219 antisense RNA 1OBI1-AS1