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Osmotic Agent (Peritoneum)
- Molecular classification
- Other
01
Overview
An osmotic agent in the context of the peritoneum refers to a solute, most commonly glucose, that is introduced into the peritoneal cavity during peritoneal dialysis (PD) to create an osmotic gradient across the peritoneal membrane. This gradient drives ultrafiltration—the movement of water from blood vessels in the peritoneum into the dialysate—by osmosis. Other osmotic agents like icodextrin or amino acids can also be used. The effectiveness depends on agent concentration, membrane permeability, and the reflection coefficient.
02
Mechanism of action
Creates crystalloid osmotic pressure gradient to drive ultrafiltration
03
Biological functions
Ultrafiltration
04
Disease associations
Renal failureFluid overload
05
Safety considerations
Hyperglycemia (with glucose)Peritoneal membrane dysfunctionElectrolyte imbalancesInfection (Peritonitis)
06
Interacting drugs
Glucose
2 more in the full profile.
07
Biomarkers
Peritoneal membrane permeabilityReflection coefficient (\(\sigma\))
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