Target intelligence / Profile preview

Outer Membrane Protein A (Porin A) P1.4 Subtype (PorA P1.4)

Target: PorA P1.4
Molecular classification: Porin, Outer Membrane Protein, Beta-barrel protein

Overview

Porin A subtype P1.4 from *N. meningitidis* is a trimeric β-barrel outer membrane protein whose surface-exposed variable regions define its immunotype and make it an important target for both natural immunity following infection and vaccine-induced protection—especially via OMV-based vaccines designed against serogroup B strains expressing this variant. It functions as a passive transport channel and a major surface antigen, eliciting bactericidal antibodies.

Other names: Porin A P1.4PorA P1.4P1.4 PorANeisseria meningitidis PorA P1.4

Mechanism of action

Antibody binding to variable regions leads to complement-mediated killing and/or opsonization, preventing bacterial survival/invasion.

Biological functions

Passive transportNutrient uptakeImmune response elicitationMembrane integrity

Disease associations

InfectionMeningitisSepticemia

Safety considerations

Potential for antigenic variationLimited serosubtype coverage in some vaccines

Interacting drugs

N/A - targeted by vaccine-induced antibodies

Biomarkers

Antibody titers against P1.4Presence of P1.4-expressing *N. meningitidis* isolates

Beyond the preview

Go deeper on Outer Membrane Protein A (Porin A) P1.4 Subtype (PorA P1.4).

Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.

Drug pipeline

Explore the programs pursuing this target and their development progress.

Drug candidates
Developers
Development stage

Clinical trials

Follow the clinical studies evaluating therapies directed at this target.

Trial design
Status
Readouts

Competitive landscape

Compare approaches across drug candidates, modalities, and indications.

Programs
Modalities
Indications

Literature & evidence

Investigate the research and source evidence behind target biology and development.

Publications
Sources
Analysis

Patents

Explore patent activity around therapies and technologies addressing this target.

Patents
Assignees
Technologies

Research & analysis

Connect target biology, drug development, and emerging evidence in your research.

Biology
Development news
Analysis

Bring the full picture into focus.

See how Gosset can support your research on Outer Membrane Protein A (Porin A) P1.4 Subtype (PorA P1.4).

Explore the full profile