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Target intelligence / Profile preview
Outer Membrane Vesicle Antigen (Neisseria meningitidis) (OMV)
- Target
- OMV
- Molecular classification
- Lipid, Protein, Glycolipid, Bacterial Outer Membrane Component
01
Overview
Outer membrane vesicles (OMVs) are nano-sized vesicles naturally shed from the outer membrane of *Neisseria meningitidis*. They are composed of lipids, proteins (e.g., PorA, OpcA, RmpM), and lipopolysaccharide (LPS). OMVs function in bacterial communication, virulence factor delivery, immune modulation, and biofilm formation. OMV-based vaccines are used against *N. meningitidis*, particularly serogroup B. Safety concerns include endotoxicity due to LPS.
- Other names
- Neisseria meningitidis Outer Membrane VesiclesNOMV (Native Outer Membrane Vesicles)dOMV (Detergent-extracted Outer Membrane Vesicles)PorA porinOpcA adhesinRmpM proteinLPS (Lipopolysaccharide)
02
Mechanism of action
N/A
03
Biological functions
Bacterial communicationVirulence factor deliveryImmune modulationBiofilm formationAntigen presentation
04
Disease associations
Meningococcal diseaseInfectionImmune response
05
Safety considerations
Endotoxicity (LPS)Reactogenicity
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