OX40 ligand (OX40L) (OX40L)

OX40 ligand (OX40L), also known as CD252 or TNFSF4, is a type II transmembrane glycoprotein expressed primarily on activated antigen-presenting cells such as dendritic cells, B cells, and macrophages, as well as some non-immune cells[5][2][3]. Its primary function is to bind the OX40 receptor (CD134, TNFRSF4) on activated T cells, especially CD4+ T cells, providing a critical costimulatory signal necessary for full T cell activation, expansion, effector function, and memory formation[2][3][6][8]. The OX40L–OX40 interaction enhances T cell survival and proliferation, supports Th1, Th2, Th17, and Tfh cell responses, and inhibits regulatory T cell activity[2][3][6]. Dysregulation of this pathway is implicated in inflammatory diseases (such as atopic dermatitis), autoimmunity, and cancer[6][8]. Therapeutic targeting of OX40L or OX40 (either blockade or agonism) is being explored in various diseases, with several monoclonal antibodies and fusion proteins in clinical development[6]. Note: The query "OX40L ligand binding OX40 receptor" refers to a ligand–receptor interaction, not a single molecule. If a single target is required, pick either "OX40 ligand" (OX40L) or "OX40 receptor" (OX40). This record describes **OX40 ligand (OX40L)**, the TNF superfamily member that binds to OX40. If structured information is required for OX40 (the receptor), a separate entry should be made. - The record is marked **is_incorrect: true** due to the improper designation as a single target; the canonical form is "OX40 ligand (OX40L)," which binds the "OX40 receptor (CD134/TNFRSF4)"[2][5].

Other names

CD252TNFSF4gp34OX40 ligandOX40LTumor necrosis factor ligand superfamily member 4Cluster of differentiation 252

Blockade of OX40L–OX40 interaction interrupts T cell costimulatory signaling, reducing effector and memory T cell numbers or function Agonist OX40L–OX40 signaling promotes T cell activity, proliferation, and cytokine secretion