Oxoglutarate dehydrogenase-like, mitochondrial (OGDHL)

Oxoglutarate dehydrogenase-like (OGDHL) is a mitochondrial enzyme and isoform of the 2-oxoglutarate dehydrogenase complex, which catalyzes a rate-limiting step in the tricarboxylic acid (TCA) cycle, essential for cellular energy production through glucose and glutamate metabolism. OGDHL acts as a tumor suppressor, modulates the AKT and potentially NF-κB signaling pathways, and is implicated in cancer prognosis, immune regulation, epithelial-mesenchymal transition, and myocardial fibrosis. It exists as multiple isoforms, is a protein-coding gene localized to mitochondria, and is considered a diagnostic and prognostic biomarker in oncology and cardiology[1][2][3][4].

Other names

2-oxoglutarate dehydrogenase-like, mitochondrialKIAA1290OGDC-E1-likeFLJ108512-oxoglutarate dehydrogenase complex component E1-likeAlpha-ketoglutarate dehydrogenase-likeYOBELN

Metabolic modulation (inhibition or activation affects glutamine dependence, energy metabolism, and redox status in cells); Potential regulation via miRNAs such as miR-3925-5p; Influences signaling pathways like AKT and NF-κB