Pannexin 1 (PANX1) (PANX1)

Pannexin 1 (PANX1) is a ubiquitously expressed glycoprotein that forms large-pore hexameric channels in the plasma membrane, primarily functioning to facilitate the regulated release of adenosine triphosphate (ATP) and other small molecules (UniProt Q96RD7). While the protein is the functional unit, PANX1 mRNA is a critical molecular target for antisense oligonucleotides and siRNA therapies designed to downregulate channel expression in pathological states (PubMed: 25633114). PANX1 is critically involved in the find-me signal during apoptosis, where its cleavage by caspases opens the channel to release ATP/UTP, attracting phagocytes (PubMed: 20833945). In disease states, PANX1 is implicated in the amplification of inflammatory responses via the NLRP3 inflammasome, the promotion of cancer cell metastasis, and the development of neuropathic pain and seizures (PubMed: 30104344). Therapeutic targeting of PANX1, either through small molecule inhibitors like probenecid or RNA-based knockdown, aims to mitigate these pathological processes in conditions such as stroke, chronic pain, and various malignancies (PubMed: 23579195).

Other names

Pannexin-1PX1MRSUNQ2529/PRO6022

Inhibition of the Pannexin 1 large-pore channel to prevent the release of pro-inflammatory and pro-apoptotic signaling molecules like ATP.