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Papilin, proteoglycan like sulfated glycoprotein (PAPLN)
- Target
- PAPLN
- Molecular classification
- Extracellular matrix glycoprotein, Proteoglycan-like protein, Serine-type endopeptidase inhibitor (predicted)
01
Overview
Papilin is a secreted extracellular matrix glycoprotein that features domains related to properdin/thrombospondin type-1 repeats and cysteine-rich regions[1]. It is predicted to regulate the extracellular environment through serine-type endopeptidase inhibitor activity and participate in the organization of basement membrane structures[2][5][6]. Human mutations in PAPLN are associated with rare connective tissue and developmental disorders, but it is not presently considered a therapeutic target for drug development[2][3].
- Other names
- PAPLNPapilinPPNUNQ2420/PRO4977MGC50452
02
Biological functions
Extracellular matrix organizationSerine-type endopeptidase inhibitor activity (predicted)Basement membrane association
03
Disease associations
Intellectual developmental disorderEhlers-Danlos syndrome, dermatosparaxis type
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