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Paraoxonase 2 (PON2) (PON2)
- Target
- PON2
- Molecular classification
- Enzyme (lactone hydrolase/arylesterase), Antioxidant protein
01
Overview
- Other names
- Paraoxonase-2PON-2mitochondrial paraoxonase-2 (context-specific)lactone hydrolase PON2
02
Biological functions
Cellular antioxidant activityProtection from oxidative stressHydrolysis of acylhomoserine lactones (bacterial quorum-sensing mediators)Defense response to pathogenic bacteriaRegulation of mitochondrial function and bioenergeticsPromotion of lipid metabolism via autophagy activationModulation of cell proliferation and apoptosis
03
Disease associations
Frontotemporal dementia and/or amyotrophic lateral sclerosis 7Apolipoprotein C-III deficiency
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