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Target intelligence / Profile preview
Penicillin-binding protein (Staphylococcus species) (PBP)
- Target
- PBP
- Molecular classification
- Enzyme, Transferase, DD-transpeptidase, Carboxypeptidase, Penicillin-binding protein family
01
Overview
- Other names
- DD-transpeptidasePeptidoglycan transpeptidasePBP1PBP2PBP3PBP4PBP2aPBP2'mecA productmecC product
02
Mechanism of action
Beta-lactam antibiotics act as structural analogs of the D-alanyl-D-alanine terminus of peptidoglycan precursors, covalently binding to the active site serine of penicillin-binding proteins (PBPs) (Bush & Bradford, 2016, Cold Spring Harb Perspect Med). This irreversible inhibition prevents the transpeptidation reaction required for peptidoglycan cross-linking, leading to a weakened cell wall, triggering of autolysins, and eventual bacterial cell lysis (Sauvage et al., 2008, FEMS Microbiol Rev).
03
Biological functions
Cell wall biosynthesisPeptidoglycan cross-linkingCell divisionMaintenance of cell morphologyPeptidoglycan metabolism
04
Disease associations
InfectionBacteremiaSepsisSkin and soft tissue infectionPneumoniaEndocarditisOsteomyelitis
05
Safety considerations
Development of antimicrobial resistance (e.g., MRSA)Hypersensitivity reactions (anaphylaxis)Cross-reactivity}
06
Interacting drugs
Penicillin G
9 more in the full profile.
07
Biomarkers
mecA genemecC genePBP2a protein expressionOxacillin minimum inhibitory concentration (MIC)Cefoxitin susceptibility
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