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Pepsinogen 3, group I (pepsinogen A) (PGA3)
- Target
- PGA3
- Molecular classification
- Enzyme, Aspartic-type endopeptidase, Peptidase A1 family
01
Overview
Pepsinogen 3, group I (pepsinogen A) (PGA3) is a zymogen (inactive precursor) of the digestive enzyme pepsin, part of the peptidase A1 family of aspartic endopeptidases. It is produced and secreted by gastric chief cells in the stomach, where it is autocatalytically cleaved in acidic gastric juice to form the active protease pepsin. Pepsin catalyzes the breakdown of dietary proteins into peptides, playing a crucial role in gastric digestion. Serum levels of pepsinogen A can be used as a biomarker for certain gastric diseases, notably atrophic gastritis and gastric cancer. PGA3 is encoded by a gene found in a cluster of pepsinogen genes on human chromosome 11
- Other names
- Pepsinogen A3Pepsin A-3Pepsinogen-3Pepsin APepsinogen 3, Group I (pepsinogen A)PGA3
02
Mechanism of action
Proteolytic cleavage of peptide bonds in acidic conditions Converts to pepsin under low pH, becoming catalytically active
03
Biological functions
Protein digestionProteolysisMetabolic processing of dietary proteins
04
Disease associations
Gastric cancerAtrophic gastritisOther gastric diseases (as a biomarker)
05
Safety considerations
Not a direct therapeutic target; no notable safety concerns as a drug target are reported
06
Biomarkers
Serum pepsinogen levels (for atrophic gastritis and gastric cancer diagnosis and monitoring)
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