Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Peptide deformylase, mitochondrial (HsPDF)
- Target
- HsPDF
- Molecular classification
- Enzyme, Metalloprotease
01
Overview
Peptide deformylase, mitochondrial (HsPDF), is a metalloprotease enzyme located in human mitochondria. It removes the formyl group from the N-terminal methionine of newly synthesized mitochondrial proteins, which is crucial for their maturation and function. HsPDF is considered a potential anticancer target, as its inhibition can disrupt mitochondrial function and selectively inhibit tumor cell proliferation.
- Other names
- PDFPDF1A
02
Mechanism of action
Inhibition of peptide deformylase activity leading to disruption of mitochondrial protein maturation and oxidative phosphorylation
03
Biological functions
Protein processingMitochondrial protein maturationRegulation of oxidative phosphorylationCell proliferationCell survival
04
Disease associations
Cancer
05
Safety considerations
Potential for off-target effects of inhibitorsMitochondrial toxicity
06
Interacting drugs
Actinonin
Beyond the preview
Go deeper on Peptide deformylase, mitochondrial (HsPDF).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Peptide deformylase, mitochondrial (HsPDF).