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Peptidyl Transferase (Bacterial) (None)

Target: None
Molecular classification: Ribozyme, Aminoacyltransferase

Overview

Peptidyl transferase is a ribozyme located in the large subunit of the bacterial ribosome. It catalyzes peptide bond formation between adjacent amino acids during protein synthesis. The enzyme is not a protein but rather an activity of ribosomal RNA (23S rRNA), making it one of the most prominent examples of catalytic RNA. The peptidyl transferase center is targeted by several classes of antibiotics that inhibit bacterial protein synthesis.

Mechanism of action

Inhibition of peptide bond formation

Biological functions

Peptide bond formationProtein synthesisHydrolysis of peptidyl-tRNA

Disease associations

Infection

Safety considerations

Off-target effects on mitochondrial ribosomes (structural similarity)Development of antibiotic resistance

Interacting drugs

Chloramphenicol

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