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Target intelligence / Profile preview
Peptidyl Transferase (Bacterial Ribosome) (PTC)
- Target
- PTC
- Molecular classification
- Ribozyme, RNA, Enzyme
01
Overview
Peptidyl transferase is a ribozyme located in the large subunit of the bacterial ribosome, specifically within the 23S rRNA component of the 50S subunit. It catalyzes peptide bond formation between adjacent amino acids during protein synthesis and is also responsible for peptidyl-tRNA hydrolysis, which releases the newly synthesized polypeptide at translation termination. Many antibiotics target this center to inhibit bacterial protein synthesis.
- Other names
- Peptidyltransferase centerRibosomal peptidyl transferase
02
Mechanism of action
Inhibition of peptide bond formation by binding to the peptidyl transferase center
03
Biological functions
Peptide bond formationPeptidyl-tRNA hydrolysisTranslation elongationTranslation terminationProtein biosynthesis
04
Disease associations
Infection
05
Safety considerations
Antibiotic resistance
06
Interacting drugs
Chloramphenicol
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