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Target intelligence / Profile preview
Peptidyl Transferase Center (Bacterial) (PTC)
- Target
- PTC
- Molecular classification
- Ribozyme, RNA, 23S rRNA
01
Overview
The peptidyl transferase center (PTC) is the catalytic core of the large ribosomal subunit in bacteria, specifically located within the 23S ribosomal RNA of the 50S subunit. It is responsible for catalyzing peptide bond formation between adjacent amino acids and hydrolysis of peptidyl-tRNA to release the completed polypeptide chain at translation termination. Many antibiotics target bacterial protein synthesis by binding to or near the PTC.
02
Mechanism of action
Inhibition of peptide bond formation or peptide release
03
Biological functions
Peptide bond formationPeptidyl-tRNA hydrolysisTranslation elongationTranslation termination
04
Disease associations
Infection
05
Safety considerations
Species-specific drug effectsAntibiotic resistance
06
Interacting drugs
Antibiotics (multiple classes)
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