Peroxiredoxin-4 (PRDX4) mRNA (PRDX4 mRNA)

Peroxiredoxin-4 (PRDX4) mRNA encodes the only member of the peroxiredoxin family localized within the endoplasmic reticulum (ER) and secreted into the extracellular space [1]. The resulting protein functions as a 2-Cys peroxiredoxin that reduces hydrogen peroxide and organic hydroperoxides, playing a critical role in maintaining redox homeostasis and facilitating oxidative protein folding by metabolizing H2O2 generated by ERO1 [2]. In various malignancies, PRDX4 is frequently upregulated, where it protects cancer cells from oxidative stress-induced apoptosis and promotes proliferation, making its mRNA a viable target for knockdown strategies [3]. Therapeutic approaches targeting PRDX4 mRNA, such as siRNA or antisense oligonucleotides, aim to sensitize tumor cells to oxidative stress and inhibit growth [4]. Beyond oncology, PRDX4 levels are associated with metabolic disorders and inflammatory states, serving as a potential biomarker for oxidative stress-related pathologies [5].

Other names

PRX-IV mRNAAOE372 mRNATRANK mRNAPeroxiredoxin IV mRNA

RNA interference (RNAi) or antisense-mediated degradation of the mRNA transcript, leading to reduced translation of the Peroxiredoxin-4 protein.