Pertactin (Bordetella pertussis) (Prn)

Pertactin (Prn) is a 69-kDa outer membrane protein of the bacterium Bordetella pertussis, belonging to the autotransporter family of proteins (UniProt P14283). It serves as a critical virulence factor by functioning as an adhesin, facilitating the attachment of the pathogen to the ciliated respiratory epithelial cells of the human host (Hijnen et al., Vaccine, 2004). In the context of acellular pertussis (aP) vaccines, pertactin is a primary antigenic component alongside pertussis toxin (PT), filamentous hemagglutinin (FHA), and fimbriae (Fim2/3) (CDC, Pertussis Vaccination). These antigens are designed to stimulate the host's immune system to produce specific antibodies that block colonization and neutralize the harmful effects of the bacteria. While highly effective, the selective pressure from vaccination has led to the global emergence of pertactin-deficient B. pertussis strains, which may impact long-term vaccine efficacy (Pawloski et al., Clin Vaccine Immunol, 2014). Despite these challenges, pertactin remains a cornerstone of modern multi-component vaccines used to prevent pertussis, commonly known as whooping cough.

Other names

P.6969-kDa outer membrane proteinAutotransporter protein pertactinBordetella pertussis acellular pertussis antigensPrn

Induction of active immunity through the production of neutralizing antibodies (IgG) against pertactin and other acellular antigens, which prevents bacterial attachment to respiratory epithelial cells and neutralizes virulence factors.