Pertussis toxin (toxoid form) (PT (for toxin), Pertussis toxoid has no established abbreviation.)

Pertussis toxoid is an inactivated form of pertussis toxin, a protein exotoxin secreted by *Bordetella pertussis* and used as the main immunogen in acellular pertussis vaccines. The native toxin is an AB5-type molecule with a catalytically active A subunit and a receptor-binding B subunit, responsible for ADP-ribosylation of Gαi subunits in host cells, disrupting GPCR signaling and contributing to the pathogenesis of whooping cough[1][3][7]. The toxoid, produced by detoxifying the toxin (commonly via chemical treatment), loses pathogenic activity but retains immunogenicity, stimulating protective antibodies against pertussis[1][7].\n\nPertussis toxoid is not classified as a therapeutic target in the context of drug development; its main role is as a *vaccine immunogen* rather than as a receptor, enzyme, transporter, or typical molecular drug target. The native pertussis toxin is used as a tool in signal transduction research and is a virulence factor in bacterial infection[3][4].

Other names

Pertussis toxoidInactivated pertussis toxin

Induces protective immune response; in native form, pertussis toxin acts via ADP-ribosylation of inhibitory G protein α-subunits, disabling G protein-coupled receptor signaling