Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR4 (MTMR4)

Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR4 (MTMR4) is an enzyme in the myotubularin-related phosphatase family that specifically dephosphorylates the D-3 position of phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5-bisphosphate, which are essential regulators of intracellular membrane trafficking and cell signaling[1][2]. MTMR4 is localized primarily to endosomal membranes (particularly late and recycling endosomes) and is often associated with the regulation of key cellular processes, including endosomal maturation, endocytic recycling, phagocytosis, and muscle homeostasis[2]. It can negatively regulate signal transduction pathways such as TGF-beta and BMP signaling by acting on Smad proteins. MTMR4 mutational defects have been linked to the neurodegenerative disorder Charcot-Marie-Tooth disease, and its interaction with ubiquitin ligase Nedd4 implicates it in the progression of muscle atrophy[1][2]. It contains a FYVE domain facilitating endosomal targeting, and is considered a molecular target due to its enzymatic role and involvement in cellular signaling regulation[1][2][3][4].

Other names

Myotubularin related protein 4KIAA0647ZFYVE11FYVE-DSP2FYVE domain-containing dual specificity protein phosphatase 2Zinc finger FYVE domain-containing protein 11

Dephosphorylation of phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5-bisphosphate to modulate cell signaling and membrane traffic; Protein dephosphorylation involved in regulation of TGF-beta/BMP signaling.