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Phosphatidylinositol-4,5-bisphosphate 4-phosphatase 1 (PIP4P1)
- Target
- PIP4P1
- Molecular classification
- Enzyme (specifically, lipid phosphatase), Transmembrane protein
01
Overview
Phosphatidylinositol-4,5-bisphosphate 4-phosphatase 1 (PIP4P1) is a transmembrane enzyme that hydrolyzes phosphatidylinositol-4,5-bisphosphate (PtdIns-4,5-P2), removing the 4-phosphate to generate phosphatidylinositol-4-phosphate (PtdIns-4-P)[4]. It plays a role in cellular lipid signaling, influences membrane trafficking events, and regulates the positioning and transport of lysosomes by recruiting JIP4 to lysosomal membranes[4]. PIP4P1 is also involved in the assembly of the lysosomal V-ATPase complex and activation of the mTORC1 pathway in response to amino acids; emerging research suggests it may have a role in cholesterol metabolism and certain cancers[4]. There are no approved drugs directly targeting PIP4P1, and its use as a clinical biomarker or drug target is still exploratory.
- Other names
- Type 1 phosphatidylinositol 4,5-bisphosphate 4-phosphataseTMEM55BC14orf9MGC26684PtdIns-4,5-P2 4-phosphatase ITransmembrane protein 55Btype I PtdIns-4,5-P(2) 4-phosphatasetype I phosphatidylinositol-4,5-bisphosphate 4-phosphatasePIP4P1
02
Biological functions
Lipid signaling regulationHydrolysis of phosphatidylinositol-4,5-bisphosphate [PtdIns-4,5-P2] to phosphatidylinositol-4-phosphate [PtdIns-4-P]Regulation of lysosomal positioning and retrograde transportRegulation of V-ATPase assembly and amino acid-dependent activation of mTORC1Potential regulation of cellular cholesterol metabolism
03
Disease associations
Deafness, Autosomal Recessive 99Lung mucoepidermoid carcinomaOther roles in cancer biology (preliminary/under investigation)
04
Safety considerations
Potential impact on lysosomal functionPossible involvement in cancer pathophysiology
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