Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha mRNA 3' untranslated region (PIK3CA mRNA 3'UTR) (PIK3CA mRNA 3'UTR)

The Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha (PIK3CA) mRNA 3' untranslated region (3'UTR) is a critical regulatory segment of the transcript encoding the p110α catalytic subunit of PI3K (Source: NCBI Gene ID 5290). This region contains multiple binding sites for microRNAs (miRNAs), such as miR-124 and miR-506, which post-transcriptionally regulate the stability and translation efficiency of the PIK3CA message (Source: PubMed, PMID: 23933340). Dysregulation of this region, often through the loss of tumor-suppressive miRNAs or shortening via alternative polyadenylation, leads to the overexpression of the PIK3CA protein (Source: PubMed, PMID: 25135935). Such overexpression drives constitutive activation of the PI3K/AKT/mTOR signaling pathway, a central regulator of cell growth, proliferation, and survival (Source: StatPearls, PI3K Mutations). Overactivation of this pathway is a hallmark of various malignancies, including breast, lung, and colorectal cancers, as well as overgrowth syndromes (Source: PubMed, PMID: 30224590). Consequently, the PIK3CA mRNA 3'UTR is an emerging therapeutic target for RNA-based interventions, such as antisense oligonucleotides (ASOs) or miRNA mimics, designed to restore translational control (Source: Nature Reviews Drug Discovery, 2020). These strategies aim to reduce oncogenic PI3K signaling by promoting mRNA degradation or blocking translation (Source: PubMed, PMID: 28813670). While most current PI3K inhibitors target the protein's kinase activity, targeting the mRNA offers a way to reduce the total protein pool, potentially overcoming certain resistance mechanisms (Source: Molecular Cancer, 2019).

Other names

PI3K-alpha mRNA 3'UTRp110-alpha mRNA 3'UTRPIK3CA 3'-UTRPhosphoinositide-3-kinase catalytic subunit alpha 3'UTR

Sequence-specific binding to the 3'UTR by therapeutic RNA molecules (e.g., miRNA mimics or ASOs) to induce mRNA degradation or sterically hinder translation, thereby reducing the expression of the PIK3CA protein (Source: PubMed, PMID: 23933340).