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Phosphodiesterase 1B, Calmodulin-Dependent (PDE1B)

Target: PDE1B
Molecular classification: Enzyme, Phosphodiesterase, Calmodulin-dependent phosphodiesterase

Overview

Phosphodiesterase 1B (PDE1B) is an enzyme that degrades both cAMP and cGMP, regulating intracellular concentrations of these second messengers. It is activated by calcium and calmodulin. PDE1B is a therapeutic target due to its role in signal transduction pathways. Selective inhibitors have potential in treating neurological disorders and cardiovascular diseases.

Mechanism of action

Inhibition of PDE1B activity to increase cAMP and cGMP levels.

Biological functions

Signal transductionRegulation of cAMP levelsRegulation of cGMP levelsHydrolysis of cyclic nucleotides

Disease associations

Neurological disordersCardiovascular diseases

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