Phosphoribosyl pyrophosphate synthetase 1-like 1, pseudogene (PRPS1L1 (pseudogene))

**Phosphoribosyl pyrophosphate synthetase 1-like 1, pseudogene** (*PRPS1L1 pseudogene*) is a non-protein-coding genomic element showing sequence homology to the functional human enzyme phosphoribosyl pyrophosphate synthetase 1 (PRPS1)[3][4]. Pseudogenes do not produce functional protein products; therefore, PRPS1L1 pseudogene is not considered a receptor, enzyme, or pharmacological target[4]. Pseudogenes can sometimes be transcribed at low levels, and in rare cases may be implicated in regulatory functions or confound molecular genetic assays, but there is no evidence that this pseudogene plays any role in disease or therapeutic pathways in humans[4][6]. **Key points:** - The gene product is *nonfunctional* and does **not participate in nucleotide biosynthesis or energy metabolism**[3][4]. - PRPS1L1 pseudogene is distinct from the active PRPS1 gene, which *does* encode an enzyme involved in nucleotide metabolism and drug response but is not applicable for this specific pseudogene[1]. - Pseudogenes like PRPS1L1 may complicate molecular biology assays due to sequence similarity with their parental functional genes[4]. This information is specific to the pseudogene *ENSG00000270753* and should not be confused with functional PRPS genes or characterized protein-coding targets.

Other names

Phosphoribosyl pyrophosphate synthetase 1-like 1PRPS1L1 pseudogenePRPS3 pseudogene