Pituitary tumor-transforming 3, pseudogene (PTTG3P)

Pituitary tumor-transforming 3, pseudogene (PTTG3P) is a processed pseudogene and long non-coding RNA (lncRNA) located on chromosome 8q13.1.[5] Although originally annotated as a putative protein-coding gene, PTTG3P does not generate a functional protein and instead acts as a ceRNA, modulating the expression of oncogenic genes—most notably, PTTG1 and factors such as FoxM1—by sponging regulatory microRNAs (e.g., miR-132/212-3p).[1][5] PTTG3P is consistently overexpressed in a broad range of cancers, where its upregulation drives cell cycle progression, proliferation, DNA replication, and suppression of apoptosis, and is correlated with larger tumor size, metastasis, and poor prognosis.[1][2][3][5][6] It is not a drug target in the classical sense (e.g., receptor, enzyme), but is considered an oncogenic biomarker and potential future therapeutic target due to its regulatory role in malignancy progression.

Other names

Putative pituitary tumor-transforming gene 3 proteinPTTG3PPTTG3hPTTG3PTTG1P3Securin-3rcPTTG1

Not applicable (no direct drug targeting; acts primarily through ceRNA/microRNA sponge mechanisms to regulate other oncogenes and pathways)